In most eukaryotic chromosomes, DNA is organized in quasiperiodic arrays of nucleosomes connected by linker DNA segments, yet how these arrays fold inside cells remains unclear. Using cryo electron tomography …
Researchers have explained the mechanism by which identical proteins manage to organise themselves and form the perfectly symmetrical capsids of most viruses Single-stranded RNA (ssRNA) viruses represent the largest and …
DNA compaction in viral capsids or chromosomes combines high density and curvature. The microscopic forces governing these assemblies are poorly understood. Shape matters in the interactions at work. Helices in …
DNA packaging within viruses, chromosomes or nano-devices leads to extremely compact assemblies where not only high density but also very high curvature prevail. Yet DNA is a rather stiff filament, …
In Eukaryotes, DNA is regularly wound into a left-handed super-helix around the histone octamer to form a chain of nucleosomes. Atomic structures have been obtained by crystallography of engineered nucleosomes. …
