In most eukaryotic chromosomes, DNA is organized in quasiperiodic arrays of nucleosomes connected by linker DNA segments, yet how these arrays fold inside cells remains unclear. Using cryo electron tomography …
Researchers have explained the mechanism by which identical proteins manage to organise themselves and form the perfectly symmetrical capsids of most viruses Single-stranded RNA (ssRNA) viruses represent the largest and …
Tamizhmalar SUNDARARAJAN has defended her PhD thesis entitled Liquid-liquid phase separation of RNA/peptide biomolecular condensates under passive and active conditions, under the supervision of Guillaume TRESSET on December 18, 2025. …
On November 18th 2025, Fatima Taiki has defended her PhD thesis entitled “Optimization of vitreous cryo-sectioning for cryo electron tomography imaging of eukaryotic chromosomes in situ”, realized under the supervision …
DNA compaction in viral capsids or chromosomes combines high density and curvature. The microscopic forces governing these assemblies are poorly understood. Shape matters in the interactions at work. Helices in …
On December 9th 2024, Kahina Vertchik has defended her PhD thesis entitled “Order and disorder in condensed DNA toroids analysed by cryo-electron microscopy”, under the supervision of Amélie LEFORESTIER and …
Thomas BUGEA has defended his PhD thesis entitled Visualising the self-assembly mechanisms of icosahedral viruses through fluorescence microscopy at the single molecule level under the supervision of Karen PERRONET and …
Kalouna KRA has defended her PhD thesis entitled Structural study at high spatio-temporal resolution of the effects of hepatitis B virus capsid assembly modulators under the supervision of Stéphane BRESSANELLI …
More than 292 million people are chronically infected with the Hepatitis B Virus (HBV), mainly in Africa and South Asia, due to the lack of systematic vaccination. HBV causes severe pathologies such as liver cirrhosis and hepatocellular carcinoma, sometimes leading to the death of almost a million patients …
Cryo electron microscopy (cryo-EM) has become an effective and straightforward approach to determine the structure of macromolecules in solution, trapped within a thin film (a few tens of nanometres) vitrified …
