In most eukaryotic chromosomes, DNA is organized in quasiperiodic arrays of nucleosomes connected by linker DNA segments, yet how these arrays fold inside cells remains unclear. Using cryo electron tomography …
On November 18th 2025, Fatima Taiki has defended her PhD thesis entitled “Optimization of vitreous cryo-sectioning for cryo electron tomography imaging of eukaryotic chromosomes in situ”, realized under the supervision …
DNA compaction in viral capsids or chromosomes combines high density and curvature. The microscopic forces governing these assemblies are poorly understood. Shape matters in the interactions at work. Helices in …
On December 9th 2024, Kahina Vertchik has defended her PhD thesis entitled “Order and disorder in condensed DNA toroids analysed by cryo-electron microscopy”, under the supervision of Amélie LEFORESTIER and …
Cryo electron microscopy (cryo-EM) has become an effective and straightforward approach to determine the structure of macromolecules in solution, trapped within a thin film (a few tens of nanometres) vitrified …
Mohamad HARASTANI has defended his PhD thesis entitled “Image analysis method development for in vitro and in situ cryo electron tomography studies of conformational variability of biomolecular complexes: case of …
DNA packaging within viruses, chromosomes or nano-devices leads to extremely compact assemblies where not only high density but also very high curvature prevail. Yet DNA is a rather stiff filament, …
RNA viruses are a family of infectious agents with sometimes dramatic health and economic consequences such as those we are currently experiencing. Over the course of a life cycle, viral …
Maelenn CHEVREUIL has defended her PhD thesis entitled Self-assembly and disassembly dynamical phenomena in icosahedral viruses under the supervision of Stéphane BRESSANELLI and Guillaume TRESSET on February 24, 2020. The …
In Eukaryotes, DNA is regularly wound into a left-handed super-helix around the histone octamer to form a chain of nucleosomes. Atomic structures have been obtained by crystallography of engineered nucleosomes. …
