PhD defense of Kahina VERTCHIK
On December 9th 2024, Kahina Vertchik has defended her PhD thesis entitled “Order and disorder in condensed DNA toroids analysed by cryo-electron microscopy”, under the supervision of Amélie LEFORESTIER and …
Sample formation for cryo-EM can be understood from a physico-chemical characterisation of liquid films and interfaces
Cryo electron microscopy (cryo-EM) has become an effective and straightforward approach to determine the structure of macromolecules in solution, trapped within a thin film (a few tens of nanometres) vitrified …
PhD defense of Mohamad Harastani
Mohamad HARASTANI has defended his PhD thesis entitled “Image analysis method development for in vitro and in situ cryo electron tomography studies of conformational variability of biomolecular complexes: case of …
Weaker attraction forces in curved DNA condensates
DNA packaging within viruses, chromosomes or nano-devices leads to extremely compact assemblies where not only high density but also very high curvature prevail. Yet DNA is a rather stiff filament, …
How a virus self-organizes while correcting its errors
RNA viruses are a family of infectious agents with sometimes dramatic health and economic consequences such as those we are currently experiencing. Over the course of a life cycle, viral …
PhD defense of Maelenn Chevreuil
Maelenn CHEVREUIL has defended her PhD thesis entitled Self-assembly and disassembly dynamical phenomena in icosahedral viruses under the supervision of Stéphane BRESSANELLI and Guillaume TRESSET on February 24, 2020. The …
Nucleosome conformational variability in situ and in vitro
In Eukaryotes, DNA is regularly wound into a left-handed super-helix around the histone octamer to form a chain of nucleosomes. Atomic structures have been obtained by crystallography of engineered nucleosomes. …
How do icosahedral RNA viruses package their genome?
In collaboration with the Institute of Integrative Biology of the Cell (I2BC), the Laboratoire Léon Brillouin and the European Synchrotron Radiation Facility, our team has elucidated the nonequilibrium self-assembly dynamics …
A Nobel prize for cryo electron microscopy
Jacques Dubochet, Joachim Frank and Richard Henderson have been awarded the 2017 Nobel prize for Chemistry “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution » a …
Geometry and interactions in self-assembled biological systems
On the occasion of the retirement of Françoise Livolant, the Laboratoire de Physique des Solides (LPS) and the Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS) are organising an international …