{"id":3592,"date":"2014-12-19T11:39:00","date_gmt":"2014-12-19T10:39:00","guid":{"rendered":"https:\/\/equipes.lps.u-psud.fr\/sobio\/?p=3592"},"modified":"2021-10-19T11:41:53","modified_gmt":"2021-10-19T09:41:53","slug":"comment-les-virus-embarquent-ils-uniquement-leur-materiel-genetique","status":"publish","type":"post","link":"https:\/\/equipes.lps.u-psud.fr\/sobio\/comment-les-virus-embarquent-ils-uniquement-leur-materiel-genetique\/","title":{"rendered":"Comment les virus embarquent-ils uniquement leur mat\u00e9riel g\u00e9n\u00e9tique ?"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"520\" height=\"308\" src=\"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-content\/uploads\/sites\/10\/2021\/10\/figure_fait_marquant.png\" alt=\"\" class=\"wp-image-3593\" srcset=\"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-content\/uploads\/sites\/10\/2021\/10\/figure_fait_marquant.png 520w, https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-content\/uploads\/sites\/10\/2021\/10\/figure_fait_marquant-300x178.png 300w\" sizes=\"auto, (max-width: 520px) 100vw, 520px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lorsque les prot\u00e9ines qui forment la coque d\u2019un virus s\u2019assemblent, elles encapsulent majoritairement le mat\u00e9riel g\u00e9n\u00e9tique du virus et non pas des \u00e9l\u00e9ments ext\u00e9rieurs, tels que des prot\u00e9ines ou des brins d\u2019ADN de la cellule infect\u00e9e. L\u2019hypoth\u00e8se retenue jusqu\u2019\u00e0 pr\u00e9sent pour expliquer cette s\u00e9lectivit\u00e9 \u00e9tait la reconnaissance de structure chimique sp\u00e9cifique entre la capside et le g\u00e9nome viral ou par l\u2019interm\u00e9diaire d\u2019enzymes sp\u00e9cifiques. En mettant en \u00e9vidence un nouveau m\u00e9canisme reposant uniquement sur la longueur du mat\u00e9riel embarqu\u00e9, des physiciens du Laboratoire de Physique des Solides &#8211; LPS (CNRS\/Univ. Paris-Sud) \u00e0 Orsay, de l\u2019Universit\u00e9 de Technologie de Wroc\u0142aw en Pologne et de l\u2019Institut Laue Langevin \u00e0 Grenoble viennent de montrer qu\u2019une reconnaissance sp\u00e9cifique de s\u00e9quence chimique n\u2019est pas n\u00e9cessaire pour comprendre la s\u00e9lectivit\u00e9 de l\u2019encapsulation virale. En \u00e9tudiant des assemblages synth\u00e9tiques de capsides virales contenant des polym\u00e8res, ils ont montr\u00e9 que les capsides referm\u00e9es embarquent toute la m\u00eame longueur totale de polym\u00e8re, qu\u2019il s\u2019agisse d\u2019un seul long brin ou de plusieurs brins plus courts. Ce travail confirme l\u2019hypoth\u00e8se selon laquelle c\u2019est l\u2019optimisation de l\u2019\u00e9nergie \u00e9lectrostatique d\u2019interaction entre la coque et le mat\u00e9riel embarqu\u00e9 qui r\u00e9git la fermeture de la capside virale. Ce travail est publi\u00e9 dans la revue <em>Physical Review Letters<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Voir aussi : <a href=\"https:\/\/archives.cnrs.fr\/inp\/article\/1443\" data-type=\"URL\" data-id=\"https:\/\/archives.cnrs.fr\/inp\/article\/1443\" target=\"_blank\" rel=\"noreferrer noopener\">Actualit\u00e9s de l&rsquo;INP<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tresset, G., Tatou, M., Le C\u0153ur, C., Zeghal, M., Bailleux, V., Lecchi, A., &#8230; &amp; Porcar, L. (2014). Weighing polyelectrolytes packaged in viruslike particles. <em>Physical review letters<\/em>, <em>113<\/em>(12), 128305.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lorsque les prot\u00e9ines qui forment la coque d\u2019un virus s\u2019assemblent, elles encapsulent majoritairement le mat\u00e9riel g\u00e9n\u00e9tique du virus et non pas des \u00e9l\u00e9ments ext\u00e9rieurs, tels que des prot\u00e9ines ou des &#8230;<\/p>\n","protected":false},"author":21,"featured_media":3594,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3592","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/posts\/3592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/comments?post=3592"}],"version-history":[{"count":1,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/posts\/3592\/revisions"}],"predecessor-version":[{"id":3595,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/posts\/3592\/revisions\/3595"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/media\/3594"}],"wp:attachment":[{"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/media?parent=3592"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/categories?post=3592"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/tags?post=3592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}