{"id":2996,"date":"2020-02-20T15:46:00","date_gmt":"2020-02-20T14:46:00","guid":{"rendered":"https:\/\/vmtest.lps.u-psud.fr\/testequipe\/?p=2996"},"modified":"2023-08-03T11:46:24","modified_gmt":"2023-08-03T09:46:24","slug":"masked-group-picture","status":"publish","type":"post","link":"https:\/\/equipes.lps.u-psud.fr\/sobio\/masked-group-picture\/","title":{"rendered":"PhD defense of Maelenn Chevreuil"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Maelenn CHEVREUIL has defended her PhD thesis entitled <strong>Self-assembly and disassembly dynamical phenomena in icosahedral viruses<\/strong> under the supervision of St\u00e9phane BRESSANELLI and Guillaume TRESSET on February 24, 2020.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"724\" height=\"1024\" src=\"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-content\/uploads\/sites\/10\/2023\/08\/Affiche-724x1024.jpg\" alt=\"\" class=\"wp-image-3804\" srcset=\"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-content\/uploads\/sites\/10\/2023\/08\/Affiche-724x1024.jpg 724w, https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-content\/uploads\/sites\/10\/2023\/08\/Affiche-212x300.jpg 212w, https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-content\/uploads\/sites\/10\/2023\/08\/Affiche-768x1087.jpg 768w, https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-content\/uploads\/sites\/10\/2023\/08\/Affiche.jpg 826w\" sizes=\"auto, (max-width: 724px) 100vw, 724px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">The self-assembly and disassembly of virus capsids, critical stages of the viral cycle, is a subject that arouses a lot of interest. However, the underlying mechanisms and, in particular, the kinetic pathways of assembly and disassembly, whether the capsid is empty or full, are not entirely solved. Time-resolved small-angle X-ray scattering is a technique for tracking processes involving nano-sized species with a time resolution of the millisecond order. Thus, in the case of the cowpea chlorotic mottle virus (CCMV), we have studied the self-assembly dynamics of capsid proteins with their genetic material. The experiments revealed the formation of amorphous complexes via a kinetic pathway called en masse whereas their relaxation into virions occurs via a so-called synchronous kinetic path. In the case of the hepatitis B virus (HBV), we were able to identify a probable disassembly kinetic path with the presence of an intermediate species organised like a fractal-branched structure. Finally, the assembly experiments revealed a kinetic pathway in three phases, i.e. agglomeration, growth and relaxation, directed by hydrophobic attraction and modulated by electrostatic repulsion.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maelenn CHEVREUIL has defended her PhD thesis entitled Self-assembly and disassembly dynamical phenomena in icosahedral viruses under the supervision of St\u00e9phane BRESSANELLI and Guillaume TRESSET on February 24, 2020. The &#8230;<\/p>\n","protected":false},"author":21,"featured_media":3804,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[8],"class_list":["post-2996","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-event"],"_links":{"self":[{"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/posts\/2996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/comments?post=2996"}],"version-history":[{"count":6,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/posts\/2996\/revisions"}],"predecessor-version":[{"id":3807,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/posts\/2996\/revisions\/3807"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/media\/3804"}],"wp:attachment":[{"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/media?parent=2996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/categories?post=2996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/equipes.lps.u-psud.fr\/sobio\/wp-json\/wp\/v2\/tags?post=2996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}